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The Manticore is a lion-like creature that appears in the minicomic Dragon's Gift guarding Skytree. Its tail seemingly has a poison stinger. He-Man defeats the Manticore by grabbing it by the tail and throwing it.
In the Filmation version of He-Man and the Masters of the Universe, the Manticore in "The Dragon's Gift" is replaced by Tullamore. However, a Manticore appears in "Orko's Favorite Uncle" when Tauron's summoning spell traps Prince Adam, Cringer, and Orko in its cave. Thankfully, Adam manages to turn into He-Man and knocks the Manticore out by throwing it into a wall, then punches his way out of its cave and blocks the entrance with a boulder before the Manticore can follow them.