In the episode Quest for the Crystals, when the trithuseum generator was destroyed on Primus, He-Man was forced to journey to Denebria to find trithuseum crystals. He encountered Meliac in a Gorn City tavern, and arranged to meet him at a nearby mine to get the crystals. Little did He-Man know that Meliac had already been contacted by Skeletor, who had promised him a great reward for taking care of He-Man. Meliac and his henchmen battled He-Man in the mine, and were ultimately defeated before Skeletor arrived to punish Meliac for his failure. Just before plunging into a deep pit, he was saved by He-Man, the act of kindness from the hero beginning a friendship between the two.
Meliac remained the contact of the Primans on Denebria following He-Mans act of kindness, showing no loyalty to the Mutants that ruled the planet. Meliac would provide the Primans with information on the Mutants activities, or help them whenever they visited the planet.
Meliac is often assisted by a group of cycloptic creatures like himself.